BIOS-01. MANAGEMENT OF OPTIC PATHWAY GLIOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract In the current study, we systematically review literature regarding management of optic pathway glioma (OPG). This will analyze demographics, information type treatment, radiological and clinical (visual) outcomes, also complications. Article selection was performed by searching PubMed, Web Science, Cochrane databases. Of 105 eligible studies, a total 4177 patients underwent different therapeutic modalities including surgery, radiotherapy, chemotherapy. The mean age 8.17 years gender ratio 97 males per 100 females. Based on available data, follow-up 98.6 months 48.7% were known cases neurofibromatosis type1. According to Dodge classification 1104, 941, 1353 tumors D1, D2, D3, respectively. toxicity induced either chemo- or radiotherapy most common complication, followed ophthalmologic complications rather than visual acuity exacerbation. pooled mortality rate 0.12 (95%CI 0.09–0.14). Due unrepresentative improved not changed outcomes classified as favorable outcome worsened an unfavorable. Meta-analyses determine outcomes. terms assessment, in chemotherapy, surgery 0.74, 0.81, 0.65, respectively overall is 0.75 0.70–0.80). following 0.71, 0.67, 0.71 0.65–0.76). subgroup analysis revealed no significant difference between treatment (P > 0.05). Our analyses showed that each modality represents viable options achieve remission for these patients.